Sanofi-Aventis
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Lab Head, Target Discovery & Validation |
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| Post Date: | Jan 30, 2012 | Type: | Full-Time |
| Start Date: | 1/30/2012 | Salary: | - n/a - |
| Location: |
US-MA-Cambridge
| Job Reference: | R&D15976 |
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Description
Sanofi-aventis is facing the future and leading the way as the 3rd largest pharmaceutical company in the world and number 1 in Europe. Backed by a world-class R&D organization, sanofi-aventis is developing leading positions in seven therapeutic areas: cardiovascular disease, thrombosis, oncology, diabetes, central nervous system, internal medicine, and vaccines.
Embrace this opportunity to join a diverse and talented group of individuals championed to take on innovation and change in our rapidly expanding organization.
Lab- Head, Target Discovery ? Validation
We are seeking a highly motivated scientist with a background in oncology target discovery, ID and Validation with a strong emphasis on Biologics targets, and a strong publication record. The successful candidate will be expected to lead a team in the target ID and validation section of Oncology. As a lead scientist you will initiate understanding and validation of novel biologic targets and establish cancer dependency. Candidates with experience in validating functional antibody targets, 3D culture systems and primary tumor cell cultures are highly desired. Alternative models of drug resistance such cancer stem cells is a plus. Knowledge of core oncogenic signaling pathways, role of tumor stroma is desired. This position requires excellent organizational skills and the ability to work in a highly collaborative environment, and interface with drug discovery and translational medicine groups. This position requires a detailed knowledge of cutting-edge molecular, biochemical and cellular drug discovery approaches and an ability to excel in a goal-oriented, multifaceted and fast-moving environment. Prior drug discovery, target identification and supervisory experience in a biotech or pharma setting are highly desirable. Additionally, the candidate is expected to lead research associates in activities ranging from target validation and assay development to cellular screens and exploration of mechanism of action of leads.
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Job Requirements
Minimum Requirements:
PhD and postdoc in cancer biology or related field, with excellent publication record
3-5 years industry/relevant experience with hands-on background working with matrixed project teams
Target validation experience with Biologic targets
Strong conceptual understanding of basic cancer signaling pathways
Independent, self motivated and innovative
Excellent written and oral communication skills
Excellent interpersonal and team skills; track record of success working collaboratively
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