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Post Doctoral Fellow - Will Hendrick's Lab
Post Date:Aug 25, 2017Type:Full time
Start Date:- n/a -Salary:- n/a -
Location: United States   Arizona - Phoenix Job Reference:- n/a -

Dr. William Hendricks at the Translational Genomics Research Institute (TGen) is currently seeking a postdoctoral research fellow to lead studies of the genetic basis of naturally occurring canine cancers to aid both dog and human in the cancer clinic. Our lab aims to understand the genomic landscape of these cancers to enable personalized medicine and shepherd novel cancer treatments through comparative clinical trials. By closely working with veterinary and academic collaborators, we seek to rapidly translate laboratory findings to the clinic.

Detailed Description

Despite decades of progress in the clinical management of cancer and amidst recent innovations in genomics-guided medicine, we are still incapable of curing most patients who are diagnosed with advanced cancers. Our laboratory focuses on shifting paradigms in cancer treatment to enable cures through programs at the intersection of personalized medicine and comparative genomics.

Dissecting biological determinants of therapeutic vulnerability in human melanoma through integrated analysis of large-scale data sets. As part of the Stand Up to Cancer and Melanoma Research Alliance Dream Team we are directing a clinical trial evaluating the hypothesis that genomics-guided drug selection can outperform physician-guided treatment in melanoma patients. Our laboratory is also working to characterize the biology of therapeutic sensitivity in melanoma cell lines through integrated analysis of comprehensive genomic, proteomic, and therapeutic data (including exome sequencing, array CGH, gene expression profiling, proteomic profiling, and high-throughput RNAi and drug screens). Hypotheses tested in vitro are contextualized through ongoing genomic analysis conducted in patient samples collected during the course of the genomics-guided clinical trial and alongside data available through public portals such as the TCGA.

Mapping canine cancer landscapes for identification of actionable targets to guide comparative clinical trials. The work described above will support development of targeted inhibitors and combinations to spur further survival gains in human melanoma. Yet, testing novel agents, combinations, and dosing schedules can be challenging in human clinical trials due to their restrictive nature. Thus, we have turned to comparative oncology where it has long been recognized that extraordinary potential lies in aligning studies of sporadic cancers in pet dogs with drug development in human cancers. To this end we have mapped the genomic landscape of canine mucosal melanoma, a common and lethal cancer in dogs that is equally deadly, but far less common, in humans. Integrated analysis has revealed genomic landscapes that resemble the human disease while also identifying novel therapeutically-relevant mutations that are reshaping our understanding of the human disease. We are now pursuing integrated comparative analysis of additional tumor types while these data are informing the development of comparative veterinary trials.

Integrating genomic and therapeutic analyses of pediatric cancers. We have recently discovered frequent inactivating mutations in and concomitant loss of the tumor suppressor SMARCA4 in the majority of cases of a rare cancer that afflicts girls and young women - small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). This mutation occurs amidst an otherwise stable cancer genome and thus provides a unique opportunity to study an isolated driver mutation of relevance to more genomically complex cancers with higher mutation rates (such as melanoma). More importantly, it provides a clear target in an extremely rare cancer for our ongoing pursuit of an empirically-derived therapeutic option for these underserved patients.

Duties and Responsibilities

Under general direction from Dr. Hendricks, the postdoctoral fellow will be responsible for:
•Designing and implementing research studies
•Collecting and analyzing data
•Writing progress reports and presenting research findings in lab meetings
•Coordinating with other research groups and institutions on collaborative research studies
•Mentoring graduate students, trainees, and junior team members
•Preparing research results for publication
•Presenting research at national meetings
•Assisting in the preparation of grant proposals

About TGen
Translational Genomics Research Institute (TGen) is a Phoenix, Arizona-based non-profit organization dedicated to conducting groundbreaking research with life changing results. TGen is focused on helping patients with neurological disorders, cancer, and diabetes, through cutting edge translational research (the process of rapidly moving research towards patient benefit). TGen physicians and scientists work to unravel the genetic components of both common and rare complex diseases in adults and children. Working with collaborators in the scientific and medical communities literally worldwide, TGen makes a substantial contribution to help our patients through efficiency and effectiveness of the translational process. TGen is allied with City of Hope, a world-renowned independent research and cancer and diabetes treatment center. This precision medicine alliance enables both institutes to complement each other in research and patient care, with City of Hope providing a significant clinical setting to advance scientific discoveries made by TGen. For more information, visit: www.tgen.org.  

Job Requirements   
•Ph.D. (completed or near completion) in Molecular Biology, Genomics or a related field is desired.
•Prior research experience or training in cancer genomics, cancer biology, and/or canine/comparative genomics is preferred
•Proven track record of creativity and established track record of publishing in peer-reviewed journals.
•Excellent written and verbal communication skills

If you are interested in seeing the most up to date job listings or to apply for this position, please go to https://www.tgen.org/postdoc and submit your resume. Please take a moment to read about our employee benefits and learn more about TGen. If you have any questions about the company or how to apply for a position, please contact HR@tgen.org.
Only resumes submitted through the TGen career website will be considered.
We value and support diversity in our workforce.

Contact Details / Apply for this Job

URL: https://www.tgen.org/home/about/careers-@-tgen.aspx#.WaBY0tiWyUk

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